Ye defo bung the cold feed & open vent if you can.
Or don't change the rad valves when replacing a rad, just isolate the valves at each side, drain the rad, replace rad, redo fittings to new rad, open valves and vent. This should prevent an airlock.
Last resort, drain the system but u obviously run the risk of airlock. I had a nitemare last Friday with an open vented combi. I've got a thread titled 'nitemare airlock' down the ch page somewhere, there's quite a few ways to cure airlocks in there.