Hi 1animal1,
I too am renovating (a Victorian house which is 2 1/2 hours away) and have already been at it 3 years! I was 'lucky' in that the house had never had central heating so was able to specify an S+ plan system comprising system gas boiler (Worcester Greenstar but not sure which model)/ ~300L unvented cylinder (unsure which brand) and three CH zones and 1 DHW zone (S+ system).
With regard to hybrid vs. S plan, I personally chose the S+ system due to the size of the house, expansion possibilities, my desire to control CH and DHW from afar, and the nature of the project in that I knew my awareness of the heating requirements would evolve as we peeled back the layers of the neglected house. Had I faced your decision, and knowing how the pipework is laid out adjacent to my boiler, I reckon I'd probably still choose to convert to an S plan setup.
My heating engineer installed the boiler, pipework and gas supply and HW cylinder last year, but since I haven't yet installed any thermostats or radiators (there will be ~20 eventually, incl. 6 towel rails), he hasn't been able to commission it yet. In the meantime, my DHW needs (which are occasional and unsubstantial) are served by an immersion heater which I have to remember to switch off! 4 hrs of immersion heating gives me at least three days' worth of scalding water - it's great. Currently, heating-wise, there's an oil-fired Rayburn and a gas-effect coal fire for the entire house!
I hope the following information doesn't digress from your question and goes some way towards helping with your decisions.
The pipework nearest my boiler so far includes 3 CH flow/return pairs of 22mm for two CH zones (1 pair for ground floor, 1 pair for upper two floors) and the third pair will feed a combined CH/UFH (UFH is <15m2) circuit for a third zone in the future. Another pair of 22mm from the boiler feeds the indirect heating coil in the HW cylinder.
So at the moment, there are 4 control valves (3 of which (2 x CH, 1 x DHW) will be controlled via two Heatlink/Nest units in the first place, and the remaining valve will be controlled by a further Nest/Heatlink when that part of the house is renovated. I plan/hope to add two further zone valves for two further UFH circuits - one for the hallway and one for an adjacent outhouse conversion. These two UFH zones will eventually be controlled by a further two Heatlinks/ Nest thermostats, so I envisage the final setup will have five Heatlinks/thermostats controlling six zone valves.
In your original post you mention the possible use of a manifold system. Although that's not exactly what I've got, it amounts to the same thing, namely from the CH flow/return boiler connections, three flow, and three return branches (via equal tees) extend and feed the three CH zones. My boiler has an integral pump.
I've decided on Nest as although 5 x 3rd gen thermostats/Heatlinks will cost the best part of £1000, Honeywell's Evohome will cost at least twice that (and I can't justify the individual room control to myself or SWMBO), I'm wary of tying myself to BG's Hive, and no-one seems to be raving about Worcester's Wave. I haven't really looked into any others in detail (e.g.Tado). The NestWeave wireless system used by Nest may also be able to integrate into the home automation systems of the future (particularly as Nest is owned by Google - albeit with reservations about its 'big brother' connotations).
So settling on a Heatlink/Nest thermostat setup, as far as I understand it from Nest's website:
1) up to 20/Nest thermostats/Heatlinks can be controlled via the app for one property.
2) one Nest account will allow you to control two properties (i.e. each property could have up up to 20 thermostats/Heatlinks).
3) in my situation I'll use the ground floor Nest thermostat to control 6 radiators and the DHW, via two 2-port zone valves. (I don't suppose there's any need to control DHW from more than one thermostat, unless for disability reasons?)
4) first floor thermostat used to control 6 radiators and 5 towel rails on first and second floors via one 2-port zone valve.
It may help you decide one way or the other, but I could send you photos of my pipework setup/ anticipated wiring connections (for my own understanding - a professional engineer will do the actual connections).
If you'll indulge me, (hopefully on the grounds I'm helping the OP with his decision-making!)rather than beginning a new thread, can I ask: apart from controlling DHW and CH, the 3rd gen Nest thermostat allows compatibility with Open Therm boilers. I know my Worcester boiler isn't Open Therm compatible (and that Open Therm itself is a questionable benefit). So apart from the single 3rd gen thermostat I need to control the DHW, can I save some money by buying 2nd gen thermostats for the other 4 zones, or should I buy 3rd gen all round? I don't currently intend going the 'whole hog' with CO detectors, CCTV etc.
Kind regards,
Ifan
PS - 3rd gen Nest thermostat is £158.99 at Argos today instead of the usual ~£180-£200.