A calculation of DHW needs and room heat loss as well as a few other things, are required before you can work out the size of combi required.
Although being fair, combi's now days mostly seem to come in about two or three sizes and its just a matter of picking one that suites the number of rooms you want to heat and a flow rate to suite the number of draw off points in your house.
They are not like the old boilers whose output was virtually constant, a lot seem to have good modulating ability and so have quite an output range.
So you can kinda get near enough on the sizes required by looking at the top and bottom outputs of the boiler and providing you come under and over these, you should be okay. It doesn't mean that you don't have to work out what size boiler you need, its just that perhaps you don't have to be so accurate as perhaps you once did.
The old way using the Mears wheel calculator for heat loss is okay, but there is a free program called "Stars" from Stelrad one of the rad makers that is quite good.
Just put "Stelrad "Stars" program" in your browser and have a look. Its about 33Mb, I've used it on and off for years. I find though, it can tend to oversize the rads a bit, but its better to oversize than undersize.
I must admit my old Mears wheel is still in the draw, you never know do you?
But saying all that, if the installation conditions are not met for a combi i.e. water pressure okay, then its probably better to look at something else.