I wouldn't, but I don't think they would class the low pressure switch as a safety device really, just prevents the boiler from firing with low water content as an indication to the user there is low water content. You don't get this problem with an open vented because the water supply is constantly there. The PRV is the safety device on a sealed system, like the open vent on an open vented system. That would be dangerous if taken away. The over heat stat and thermisters will still work the same.
There are boilers out there that will work on a vented system, such as a Baxi Solo HE. They are a straight swap for something like an old Baxi Solo.